Publikationen 2019

Pannwitt S, Slama K, Depoix F, Helm M, Schneider D.
“Against expectations: Unassisted RNA adsorption onto negatively charged lipid bilayers”
Langmuir. 2019 Oct 18
DOI: 10.1021/acs.langmuir.9b02830 [Epub ahead of print]

Tabujew I, Willig M, Leber N, Freidel C, Negwer I, Koynov K, Helm M, Landfester K, Zentel R, Peneva K, Mailänder V.
“Overcoming the Barrier of CD8+ T Cells: Two types of Nano-Sized Carriers for siRNA Transport”
Acta Biomater. 2019 Oct 3. pii: S1742-7061(19)30673-7.
DOI: 10.1016/j.actbio.2019.10.006 [Epub ahead of print]

Die Nano-Bio-Grenzfläche: Analyse der Proteinkorona als Schlüssel für die biomedizinische Anwendung von Nanocarriern
GIT-Laborfachzeitschrift (2019)

K. Landfester
“Einführung in die Bio- und Medizinphysik In “Vielfältige Physik - Wissenschaftlerinnen schreiben über ihre Forschung“ D. Duchardt, A.B. Bossmann, A.C. Denz (Hrsg.)”
Springer (2019), Weinheim, p. 265 – 271.

B. Iyisan, K. Landfester
“Polymeric Nanoparticles” in "Biological Responses to Nanoscale Particles: Molecular and Cellular Aspects and Methodological Approaches”
Springer Nature, Heidelberg p. 52 – 84

B. Iyisan, K. Landfester
“Modular Approach for the Design of Smart Polymeric Nanocapsules ”
Macromol. Rapid Commun. 40, Art. No. 1800577
DOI: 10.1002/marc.201800577

D. Prozeller, J. Pereira, J. Simon, V. Mailänder, S. Morsbach, K. Landfester
“Prevention of Dominant IgG Adsorption on Nanocarriers in IgG-Enriched Blood Plasma by Clusterin Precoating”
Adv. Sci. 6, Art. No. 1802199
DOI: 10.1021/acs.biomac.9b00539

A.K. Danner, S. Schöttler, E. Alexandrino, S. Hammer, K. Landfester, V. Mailänder, S. Morsbach, H. Frey, F.R. Wurm
“Phosphonylation Controls the Protein Corona of Multifunctional Polyglycerol-Modified Nanocarriers”
Macromol. Biosci. 19, Art. No. 1800468
DOI: 10.1002/mabi.201800468

C. Weber, M. Voigt, J. Simon, A.K. Danner, H. Frey, V. Mailänder, M. Helm, S. Morsbach, K. Landfester
“Functionalization of Liposomes with Hydrophilic Polymers Results in Macrophage Uptake Independent of the Protein Corona”
Biomacromolecules 20, 2989-2999
DOI: 10.1021/acs.biomac.9b00539

C. Weber, S. Morsbach, K. Landfester
“Possibilities and Limitations of Different Separation Techniques for the Analysis of the Protein Corona”
Angew. Chem. Intern. Ed. 10.1002/anie.201902323
DOI: 10.1002/anie.201902323

R.M. Visalakshan, M.N. MacGregor, S. Sasidharan, A. Ghazaryan, A.M. Mierczynska-Vasilev, S. Morsbach, V. Mailänder, K. Landfester, J.D. Hayball, K. Vasilev
“Biomaterial Surface Hydrophobicity-Mediated Serum Protein Adsorption and Immune Responses”
ACS Appl. Mater. Interf. 11, 27615-27623
DOI: 10.1021/acsami.9b09900

Pektor S, Schlöder J, Klasen B, Bausbacher N, Wagner DC, Schreckenberger M, Grabbe S, Jonuleit H, Miederer M.
“Using immuno-PET imaging to monitor kinetics of T cell-mediated inflammation and treatment efficiency in a humanized mouse model for GvHD”
Eur J Nucl Med Mol Imaging Aug 31
DOI: 10.1007/s00259-019-04507-0

Renner K, Bruss C, Schnell A, Koehl G, Becker HM, Fante M, Menevse AN, Kauer N, Blazquez R, Hacker L, Decking SM, Bohn T, Faerber S, Evert K, Aigle L, Amslinger S, Landa M, Krijgsman O, Rozeman EA, Brummer C, Siska PJ, Singer K, Pektor S, Miederer M, Peter K, Gottfried E, Herr W, Marchiq I, Pouyssegur J, Roush WR, Ong S, Warren S, Pukrop T, Beckhove P, Lang SA, Bopp T, Blank CU, Cleveland JL, Oefner PJ, Dettmer K, Selby M, Kreutz M.
“Restricting Glycolysis Preserves T Cell Effector Functions and Augments Checkpoint Therapy”
Cell Rep. Oct 1;29(1):135-150.e9
DOI: 10.1016/j.celrep.2019.08.068

Stergiou N, Nagel J, Pektor S, Heimes AS, Jäkel J, Brenner W, Schmidt M, Miederer M, Kunz H, Roesch F, Schmitt E.
“Evaluation of a novel monoclonal antibody against tumor-associated MUC1 for diagnosis and prognosis of breast cancer”
Int J Med Sci. Aug 14;16(9):1188-1198
DOI: 10.7150/ijms.35452. eCollection 2019

Jana De Vrieze, Benoit Louage, Kim Deswarte, Zifu Zhong, Ruben De Coen, Simon Van Herck, Lutz Nuhn, Camilla Kaas Frich, Alexander N. Zelikin, Stefan Lienenklaus, Niek N. Sanders, Bart N. Lambrecht, Sunil A. David, Bruno G. De Geest
“Potent lymphatic translocation and spatial control over innate immune activation by polymer-lipid amphiphile conjugates of small molecule TLR7/8 agonists”
Angewandte Chemie International Edition 2019, 1900120
DOI: 10.1002/anie.20190568

B. Steinborn, P. Hirschle, M. Höhn, T. Bauer, M. Barz, S. Wuttke, E. Wagner, U. Lächelt
“Core-Shell Functionalized Zirconium-Pemetrexed Coordination Nanoparticles as Carriers with a High Drug Content ”
Adv Therapeutics 2019, 1900120
DOI: 10.1002/adtp.201900120

D.M. Loy, P.M. Klein, R. Krzysztoń, U. Lächelt, J.O. Rädler, E. Wagner
“A microfluidic approach for sequential assembly of siRNA polyplexes with a defined structure – activity relationship ”
PeerJ Materials Science 2019, 1-37
DOI: 10.7717/peerj-matsci.1

L. Peng, E. Wagner
“Polymeric Carriers for Nucleic Acid Delivery: Current Designs and Future Directions ”
Biomacromolecules 2019, 20, 3613-3626
DOI: 10.1021/acs.biomac.9b00999

Stefan Kramer, Jens Langhanki, Matthias Krumb, Till Opatz, Matthias Bros, and Rudolf Zentel
“HPMA-Based Nanocarriers for Effective Immune System Stimulation ”
Org. Macromol. Biosci. 2019, 19, 1800481
DOI: 10.1002/mabi.201800481

Ana de la Fuente, Stefan Kramer, Nicole Mohr, Stefanie Pektor, Benedikt Klasen, Nicole Bausbacher, Matthias Miederer, Rudolf Zentel, Frank Rösch
“68Ga-, 111In-oxine: a novel strategy of in situ radiolabeling of HPMA-based micelles”
Org. Am J Nucl Med Mol Imaging 2019, 9(1), 67–83

Nadine Leber, Leonard Kaps, Aiting Yang, Misbah Aslam, Mariacristina Giardino, Sebastian Rosigkeit, Asmaa Mostafa, Lutz Nuhn, Detlef Schuppan, Rudolf Zentel
“α-Mannosyl-Functionalized Cationic Nanohydrogel Particles for Targeted Gene Knockdown in Immunosuppressive Macrophages”
Org. Macromolecular Bioscience 2019, 19, 1900162
DOI: 10.1002/mabi.201900162

Ruben De Coen, Lutz Nuhn, Bruno G. de Geest
“Engineering mannosylated nanogels with membrane-disrupting properties”
Org. Polymer Chemistry 2019, 10, 4297-4304
DOI: 10.1039/c9py00492k

Ghazaryan, K. Landfester, V. Mailänder
“Protein deglycosylation can drastically affect the cellular uptake”
Org. Nanoscale 2019, 11, 10727-10737
DOI: 10.1039/C8NR08305C

R. Otter, P. Besenius
“Supramolecular Assembly of Functional Peptide-Polymer Conjugates”
Org. Biomol. Chem. 2019, 17, 6719-6734
DOI: 10.1039/c9ob01191a

A M Alkilany, L Zhu, H Weller, A Mews, W Parak, M Barz, N Feliu.
“Ligand Density on Nanoparticles: A Parameter with Critical Impact on Nanomedicine”
Adv. Drug Deliv. Rev. 2019
DOI: 10.1016/j.addr.2019.05.010

O Schäfer, D Schollmeyer, A Birke, R Holm, K Johann, C Muhl, C Seidl, M. Barz
“Investigation of α-amino acid N-carboxyanhydrides by X-ray diffraction for controlled ring-opening polymerization”
Tetrahedron Letters 2019, 60 (3), 272-275
DOI: 10.1016/j.tetlet.2018.12.028

Zimpel, A.; Al Danaf, N.; Steinborn, B.; Kuhn, J.; Höhn, M.; Bauer, T.; Hirschle, P.; Schrimpf, W.; Engelke, H.; Wagner, E.; Barz, M.; Lamb, D. C.; Lächelt, U.; Wuttke, S. “Coordinative Binding of Polymers to Metal–Organic Framework Nanoparticles for Control of Interactions at the Biointerface”
ACS Nano 2019, 13 (4), 3884–3895
DOI: 10.1021/acsnano.8b06287

Q Sun, M Barz, BG De Geest, M Diken, WE Hennink, F Kiessling, Twan Lammers, Yang Shi
“Nanomedicine and macroscale materials in immuno-oncology”
Chemical Society Reviews 2019, 48 (1), 351-381
DOI: 10.1039/C8CS00473K

S. Mantha, S. Qi, M. Barz, F. Schmid
“How ill-defined constituents produce well-defined nanoparticles: Effect of polymer dispersity on the uniformity of copolymeric micelles”
Physical Review Materials 2019, 3, 2, 026002
DOI: 10.1103/PhysRevMaterials.3.026002

Hansel C, Erschfeld S, Baues M, Lammers T, Weiskirchen R, Trautwein C, Kroy DC, Drescher HK.
„The Inhibitory T Cell Receptors PD1 and 2B4 Are Differentially Regulated on CD4 and CD8 T Cells in a Mouse Model of Non-alcoholic Steatohepatitis”
Front Pharmacol. 2019, 10, 244.
DOI: 10.3389/fphar.2019.00244

Sun Q, Baues M, Klinkhammer BM, Ehling J, Djudjaj S, Drude NI, Daniel C, Amann K, Kramann R, Kim H, Saez-Rodriguez J, Weiskirchen R, Onthank DC, Botnar RM, Kiessling F, Floege J, Lammers T, Boor P.
“Elastin imaging enables noninvasive staging and treatment monitoring of kidney fibrosis”
Sci Transl Med. 2019, 11, 486.
DOI: 10.1126/scitranslmed.aat4865

Ergen C, Niemietz PM, Heymann F, Baues M, Gremse F, Pola R, van Bloois L, Storm G, Kiessling F, Trautwein C, Luedde T, Lammers T, Tacke F.
“Liver fibrosis affects the targeting properties of drug delivery systems to macrophage subsets in vivo”
Biomaterials. 2019, 206, 49-60.
DOI: 10.1016/j.biomaterials.2019.03.025

Sadeghi N, Kok RJ, Bos C, Zandvliet M, Geerts WJC, Storm G, Moonen CTW, Lammers T, Deckers R.
“Hyperthermia-triggered release of hypoxic cell radiosensitizers from temperature-sensitive liposomes improves radiotherapy efficacy in vitro”
Nanotechnology. 2019,30, 26, 264001
DOI: 10.1088/1361-6528/ab0ce6

Mossanen JC, Kohlhepp M, Wehr A, Krenkel O, Liepelt A, Roeth AA, Möckel D, Heymann F, Lammers T, Gassler N, Hermann J, Jankowski J, Neumann UP, Luedde T, Trautwein C, Tacke F.
“CXCR6 Inhibits Hepatocarcinogenesis by Promoting Natural Killer T- and CD4+ T-Cell-Dependent Control of Senescence”
Gastroenterology. 2019, 156, 6, 1877-1889
DOI: 10.1053/j.gastro.2019.01.247

Bartneck M, Schrammen PL, Möckel D, Govaere O, Liepelt A, Krenkel O, Ergen C, McCain MV, Eulberg D, Luedde T, Trautwein C, Kiessling F, Reeves H, Lammers T, Tacke F.
“The CCR2+ Macrophage Subset Promotes Pathogenic Angiogenesis for Tumor Vascularization in Fibrotic Livers”
Cell Mol Gastroenterol Hepatol. 2019, 7, 2, 371-390.
DOI: 10.1016/j.jcmgh.2018.10.007

Heinrich MA, Bansal R, Lammers T, Zhang YS, Michel Schiffelers R, Prakash J.
“3D-Bioprinted Mini-Brain: A Glioblastoma Model to Study Cellular Interactions and Therapeutics”
Adv Mater. 2019, 31, 14, e1806590
DOI: 10.1002/adma.201806590

Dadfar SM, Roemhild K, Drude NI, von Stillfried S, Knüchel R, Kiessling F, Lammers T.
“Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications”
Adv Drug Deliv Rev. 2019, 138, 302-325
DOI: 10.1016/j.addr.2019.01.005

J. Simon, S. Christmann, V. Mailänder, F.R. Wurm, K. Landfester
“Protein Corona Mediated Stealth Properties of Biocompatible Carbohydrate-based Nanocarriers”
Isr. J. Chem. 2018, 58, 1363 – 1372
DOI: 10.1002/ijch.201800166

S. Han, M. Raabe, L. Hodgson, J. Mantell, P. Verkade, T. Lasser, K. Landfester, T. Weil, I. Lieberwirth
“High-Contrast Imaging of Nanodiamonds in Cells by Energy Filtered and Correlative Light-Electron Microscopy: Toward a Quantitative Nanoparticle-Cell Analysis”
Nanoletters 2019, 19, 2178-2185
DOI: 10.1021/acs.nanolett.9b00752