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“Tumor immunoevasion via acidosis-dependent induction of regulatory tumor-associated macrophages”
Nature Immunology 2018, 19, 1319–1329.
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I. Negwer, A. Best, M. Schinnerer, O. Schäfer, L. Capeloa, M. Wagner, M. Schmidt, V. Mailänder, M. Helm, M. Barz, H.-J. Butt, K. Koynov
“Monitoring drug nanocarriers in human blood by near-infrared fluorescence correlation spectroscopy”
Nature Communications 2018, 9: 5306
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J. Reinholz, K. Landfester, V. Mailänder
„The challenges of oral drug delivery via nanocarriers”
Drug delivery 2018, 25, 1694-1705.
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D. Passlick, K. Piradashvili, D. Bamberger, M. Li, S. Jiang, D. Strand, P. Wich, K. Landfester, M. Bros, S. Grabbe, V. Mailänder
„Delivering all in one: Antigen-nanocapsule loaded with dual adjuvant yields superadditive effects by DC-directed T cell stimulation”
J. Contr. Release 2018, 289, 23-34.
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J. Simon, J. Muller, A. Ghazaryan, S. Morsbach, V. Mailänder, K. Landfester
„Protein denaturation caused by heat inactivation detrimentally affects biomolecular corona formation and cellular uptake”
Nanoscale 2018, 10, 21096-21105.
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L. Nuhn, S. De Koker, S. Van Lint, Z. Zhong, J. P. Catani, F. Combes, K. Deswarte, Y. Li, B. N. Lambrecht, S. Lienenklaus, N. N. Sanders, S. A. David, J. Tavernier, B. G. De Geest
“Nanoparticle-Conjugate TLR7/8 Agonist Localized Immunotherapy Provokes Safe Antitumoral Responses”
Adv. Mater. 2018, 30, e1803397.
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L. Lybaert, K. Vermaelen, B. G. De Geest, L. Nuhn
“Immunoengineering through Cancer Vaccines – A Personalized and Multi-Step Vaccine Approach towards Precise Cancer Immunity”
J. Controlled Release 2018, 289, 125-145.
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S. Van Herck, K. Deswarte, L. Nuhn, Z. Zhong, J. P Catani, Y. Li, N. N. Sanders, S. Lienenklaus, S. De Koker, B. N. Lambrecht, S. A. David, B. G. De Geest
“Lymph-Node-Targeted Immune Activation by Engineered Block Copolymer Amphiphiles−TLR7/8 Agonist Conjugates”
J. Am. Chem. Soc. 2018, 140, 14300-14307.
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A. Van Driessche, A. Kocere, H. Everaert, L. Nuhn, S. Van Herck, G. Griffiths, F. Fenaroli, B. G. De Geest
“pH-Sensitive Hydrazone-Linked Doxorubicin Nanogels via Polymeric-Activated Ester Scaffolds: Synthesis, Assembly, and In Vitro and In Vivo Evaluation in Tumor-Bearing Zebrafish”
Chem. Mater. 2018, 30, 8587-8596.
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G. Settanni, T. Schäfer, C. Muhl, M. Barz, F. Schmid
“Poly-Sarcosine and Poly (ethylene-glycol) interactions with proteins investigated using molecular dynamics simulations”
Computational and structural biotechnology journal 2018, 16, 543-550.
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T. Schäfer, J. Zhou, F. Schmid, G. Settanni
“Blood Proteins and Their Interactions with Nanoparticles Investigated Using Molecular Dynamics Simulations”
High Performance Computing in Science and Engineering'17 2018, 5-19.
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S. Reinhard, Y. Wang, S. Dengler, E. Wagner
“Precise Enzymatic Cleavage Sites for Improved Bioactivity of siRNA Lipo-Polyplexes”
Bioconjug Chem. 2018, 29, 3649-3657.
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S. Hager, E. Wagner
“Bioresponsive polyplexes – chemically programmed for nucleic acid delivery”
Exp. Opinion Drug Delivery 2018, 15, 1067-1083.
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F. Fenaroli, U. Repnik, Y. Xu, K. Johann, S. Van Herck, P. Dey, F. M. Skjeldal, D. M. Frei, S. Bagherifam, A. Kocere, R. Haag, B. G. De Geest, M. Barz, D. G. Russell, G. Griffiths
“Enhanced Permeability and Retention-like Extravasation of Nanoparticles from the Vasculature into Tuberculosis Granulomas in Zebrafish and Mouse Models”
ACS Nano 2018, 12 (8), 8646–8661.
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C. Muhl, O. Schäfer, T. Bauer, H.-J. Räder, M. Barz
“Poly(S -Ethylsulfonyl- l -Homocysteine): An α-Helical Polypeptide for Chemoselective Disulfide Formation”
Macromolecules 2018, 51 (20), 8188–8196.
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S. Rosigkeit, M. Meng, C. Grunwitz, P. Gomes, A. Kreft, N. Hayduk, R. Heck, G. Pickert, K. Ziegler, Y. Abassi, J. Röder, L. Kaps, F. Vascotto, T. Beissert, S. Witzel, A. Kuhn, M. Diken, S. Schuppan, U. Sahin, H. Haas, E. Bockamp
„Monitoring Translation Activity of MRNA-Loaded Nanoparticles in Mice”
Mol. Pharm. 2018, 15 (9), 3909–3919.
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F. Man, T. Lammers, R. T. M. de Rosales
“Imaging Nanomedicine-Based Drug Delivery: A Review of Clinical Studies”
Mol. Imaging Biol. 2018, 20, 683–695.
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S. K. Golombek, J.-N. May, B. Theek, L. Appold, N. Drude, F. Kiessling, T. Lammers
“Tumor Targeting via EPR: Strategies to Enhance Patient Responses”
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C. Eich, M. Fichter, F. Borgans, A. Pietrzak-Nguyen, L. Pretsch, S. Jiang, M. Li, K. Landfester, S. Gehring
“Activation of primary neonatal Dendritic Cells (DCs) through encapsulated TLR-7/8 ligand resiquimod”
Europ. J. Immunology 2018, 48, 168-169.
A. Gamarra, S. Munoz-Guerra, A. Martinez de Ilarduya, H. Therien-Aubin, K. Landfester
“Comblike Ionic Complexes of Hyaluronic Acid and Alkanoylcholine Surfactants as a Platform for Drug Delivery Systems”
Biomacromolecules 2018, 19, 3669-3681.
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C. Weber, J. Simon, V. Mailänder, S. Morsbach, K. Landfester
„Preservation of the soft protein corona in distinct flow allows identification of weakly bound proteins”
Acta Biomaterialia 2018, 76, 217-224.
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M. Tonigold, J. Simon, D. Estupinan, M. Kokkinopoulou, J. Reinholz, U. Kintzel, A. Kaltbeizel, P. Renz, M.P. Domogalla, K. Steinbrink, I. Lieberwirth, D. Crespy, K. Landfester, V. Mailänder
“Pre-adsorption of antibodies enables targeting of nanocarriers despite a biomolecular corona.
Nature Nanotech. 2018, 13, 862-869.
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S. Morsbach, G. Gonella, V. Mailänder, S. Wegner, S. Wu, T. Weidner, R. Berger, K. Koynov, D. Vollmer, N. Encinas, S.L. Kuan, T. Bereau, K. Kremer, T. Weil, M. Bonn, H.J. Butt, K. Landfester
„Engineering Proteins at Interfaces: From Complementary Characterization to Material Surfaces with Designed Functions.
Angew. Chem. Intern. Ed. 2018, 57, 12626 –12648.
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„Engineering von Proteinen an Oberflächen: Von komplementärer Charakterisierung zu Materialoberflächen mit maßgeschneiderten Funktionen“
Angewandte Chemie 2018, 130, 12806 –12830.
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S. Seneca, J. Simon, C. Weber, A. Ghazarya, A. Ethirajan, V. Mailänder, S. Morsbach, K. Landfester
“How Low Can You Go? Low Densities of Poly(ethylene glycol) Surfactants Attract Stealth Proteins”
Macromol. Biosci. 2018, 29, Article No. 1800075.
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L. Nuhn, L. Van Hoecke, K. Deswarte, B. Schepens, Y. Li, B. N. Lambrecht, S. De Koker, S. A. David, X. Saelens, B. G. De Geest
“Potent Anti-Viral Vaccine Adjuvant Based on PH-Degradable Nanogels with Covalently Linked Small Molecule Imidazoquinoline TLR7/8 Agonist”
Biomaterials 2018, 178, 643–651.
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M. Bros, L. Nuhn, S. Simon, L. Moll, V. Mailänder, K. Landfester, S. Grabbe
„The Protein Corona as a Confounding Variable of Nanoparticle-Mediated Targeted Vaccine Delivery”
Front. Immunol. 2018, 9, 1760.
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L. Nuhn, E. Bolli, S. Massa, I. Vandenberghe, K. Movahedi, B. Devreese, J. A. Van Ginderachter, B. G. De Geest
“Targeting Protumoral Tumor-Associated Macrophages with Nanobody-Functionalized Nanogels through Strain Promoted Azide Alkyne Cycloaddition Ligation”
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„FRET Monitoring of Intracellular Ketal Hydrolysis in Synthetic Nanoparticles”
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„Förster-Resonanzenergietransfer-basierter Nachweis intrazellulärer Ketal-Hydrolyse in synthetisch vernetzten Nanopartikeln“
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P. M. Klein, K. Klinker, W. Zhang, S. Kern, E. Kessel, E. Wagner, M. Barz
Efficient Shielding of Polyplexes Using Heterotelechelic Polysarcosines
Polymers, 10(6):689 (2018)
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J. Simon, L. K. Müller, M. Kokkonopouplou, I. Lieberwirth, S. Morsbach, K. Landfester, V. Mailänder
Exploiting the biomolecular corona: pre-coating of nanoparticles enables controlled cellular interactions
Nanoscale, 10, 10731–10739 (2018)
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J. Simon, T. Wolf, K. Klein, K. Landfester, F. R. Wurm, V. Mailänder
Hydrophilicity Regulates the Stealth Properties of Polyphosphoester-Coated Nanocarriers
Angew. Chem. Intern. Ed. 57, 5548-5553 (2018)
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J. Müller, D. Prozeller, A. Ghazaryan, M. Kokkinopoulou, V. Mailänder, S. Morsbach, K. Landfester
Beyond the protein corona - lipids matter for biological response of nanocarriers
Acta Biomater. 71, 420-431 (2018)
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J. Reinholz, C. Diesler, S. Schöttler, M. Kokkinopoulou, S. Ritz, K. Landfester, V. Mailänder
Protein machineries defining pathways of nanocarrier exocytosis and transcytosis
Acta Biomater. 71, 432-443 (2018)
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J. Müller, J. Simon, P. Rohne, C. Koch-Brandt, V. Mailänder, S. Morsbach, K. Landfester
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Biomacromolecules, 19, 2657-2664 (2018)
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L. Simón-Gracia, P. Scodeller, S. S. Fuentes, V. G. Vallejo, X. Ríos, E. San Sebastián, V. Sidorenko, D. Di Silvio, M. Suck, F. De Lorenzi, L. Y. Rizzo, S. von Stillfried, K. Kilk, T. Lammers, S. E. Moya, T. Teesalu, L. Simón-Gracia, P. Scodeller, S. Salazar Fuentes, V. Gómez Vallejo, X. Ríos, E. San Sebastián, V. Sidorenko, D. Di Silvio, M. Suck, F. De Lorenzi, L. Yokota Rizzo, S. von Stillfried, K. Kilk, T. Lammers, S. E. Moya, T. Teesalu
Application of polymersomes engineered to target p32 protein for detection of small breast tumors in mice
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R. Otter, N.A. Henke, C. Berac, T. Bauer, M. Barz, S. Seiffert, P. Besenius
Secondary Structure-Driven Hydrogelation using Foldable Telechelic Polymer-Peptide Conjugates
Macromol. Rapid Commun. (2018)
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B. Theek, M. Baues, F. Gremse, R. Pola, M. Pechar, I. Negwer, K. Koynov, B. Weber, M. Barz, W. Jahnen-Dechent, G. Storm, F. Kiessling, T. Lammers
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Of Thiols and Disulfides: Methods for Chemoselective Formation of Asymmetric Disulfides in Synthetic Peptides and Polymers
Chem. Eur. J. 24, 1–13 (2018)
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A. Birke, J. Ling, M. Barz
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J. Yoo, A. Birke, J. Kim, Y. Jang, S. Song, S. Ryu, B. Kim, B. Kim, M. Barz, K. Char
Cooperative Catechol-Functionalized Polypept(o)ide Brushes and Ag Nanoparticles for a Combination of Protein Resistance and Antimicrobial Activity on Metal Oxide Surfaces
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B. Weber, A. Birke, K. Fischer, M. Schmidt, M. Barz
Solution Properties of Polysarcosine: From Absolute and Relative Molar Mass Determinations to Complement Activation
Macromolecules, 51, 2653–2661 (2018)
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S. Beck, J. Schultze, H. Räder, R. Holm, M. Schinnerer, M. Barz, K. Koynov, R. Zentel
Site-Specific DBCO Modification of DEC205 Antibody Polymer Conjugation
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D. Straßburger, M. Glaffig, N. Stergiou, S. Bialas, P. Besenius, E. Schmitt, H. Kunz
Synthetic MUC1 Antitumor Vaccine with Incorporated 2,3-Sialyl-T Carbohydrate Antigen Inducing Strong Immune Responses with Isotype Specificity
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D. Straßburger, N. Stergiou, M. Urschbach, H. Yurugi, D. Spitzer, D. Schollmeyer, E. Schmitt, P. Besenius
Mannose-Decorated Multicomponent Supramolecular Polymers Trigger Effective Uptake into Antigen-Presenting Cells.
ChemBioChem 19, (2018)
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M. S. Alkanawati, F. R. Wurm, H. Therien-Aubin, K. Landfester
Large-Scale Preparation of Polymer Nanocarriers by High-Pressure Microfluidization
Macromol. Mater. Eng. 303, 1700505 (2018)
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L. K. Müller, J. Simon, V. Mailänder, S. Morsbach, K. Landfester
The Transferability from Animal Models to Humans: Challenges Regarding Aggregation and Protein Corona Formation of Nanoparticles
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L. Becker Peres, R. Silva dos Anjos, L.C. Tappertzhofen, P.E. Feuser, P.H.H. de Araújo, K. Landfester, C. Sayer, R. Muñoz-Espí
pH-responsive physically and chemically cross-linked glutamic-acid-based hydrogels and nanogels
European Polymer Journal 101, 341–349 (2018)
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I. Schlegel, P. Renz, J. Simon, I. Lieberwirth, S. Pektor, N. Bausbacher, M. Miederer, V. Mailänder, R. Muñoz-Espí, D. Crespy, K. Landfester
Highly Loaded Semipermeable Nanocapsules for Magnetic Resonance Imaging.
Macromolecular Bioscience, 1700387, 1–12 (2018)
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R. Momper, J. Steinbrecher, M. Dorn, I. Rörich, S. Bretschneider, M. Tonigold, C. Ramanan, S. Ritz, V. Mailänder, K. Landfester, M. Bannwarth
Enhanced photoluminescence properties of a carbon dot system through surface interaction with polymeric nanoparticles
J Colloid Interface Sci 518, 11–20 (2018)
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J. Simon, T. Wolf, K. Klein, K. Landfester, V. Mailänder, F. R. Wurm
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E. Eppard, A. de la Fuente, N. Mohr, M. Allmeroth, R. Zentel, M. Miederer, S. Pektor, F. Rösch
Labeling of DOTA-conjugated HPMA-based polymers with trivalent metallic radionuclides for molecular imaging
EJNMMI Research 8 (16), (2018)
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K. Wagener, D. Moderegger, M. Allmeroth, A. Reibel, S. Kramer, B. Biesalski, N. Bausbacher, R. Zentel, O. Thews, F. Rösch
Long-term biodistribution study of HPMA-ran-LMA copolymers in vivo by means of 131I-labeling
Nuclear Medicine and Biology 58, 59–66 (2018)
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P. M. Klein, S. Kern, D. J. Lee, J. Schmaus, M. Höhn, J. Gorges, U. Kazmaier, E. Wagner
Folate receptor-directed orthogonal click-functionalization of siRNA lipopolyplexes for tumor cell killing in vivo.
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S. Morys, S. Urnauer, C. Spitzweg, E. Wagner
EGFR Targeting and Shielding of pDNA Lipopolyplexes via Bivalent Attachment of a Sequence-Defined PEG Agent.
Macromol Biosci. 18 (1), (2018)
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